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KMID : 1098420100180050311
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Korean Journal of Medicinal Crop Science
2010 Volume.18 No. 5 p.311 ~ p.314
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Determination of Luteolin in the Different Parts of Lithospermum erythrorhizon by HPLC
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Han Saem
Park Jun-Yeon
Lee Sul-Lim
Mok So-Youn
Kim Hye-Min
Lee Jeong-Min
An Yeong-Hee
Lee Sang-Hyun
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Abstract
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Taxifolin-3-O-β-D-xylopyranoside and quercetin-3-O-α-L-rhamnopyranoside were isolated from an EtOAcsoluble extract of the leaves of Chamaecyparis obtuse. Quercetin-3-O-α-L-rhamnopyranoside was found to possess a potent inhibitory activity of human recombinant aldose reductase in vitro, its IC50 value being 11.5 μM. Kinetic analysis showed that quercetin-3-O-α-L-rhamnopyranoside exhibited uncompetitive inhibition against DL-glyceraldehyde. Also, quercetin- 3-O-α-L-rhamnopyranoside suppresses sorbitol accumulation in rat lens under high glucose conditions, demonstrating the potential to prevent sorbitol accumulation in vivo. These results suggest that this compound may be a promising agent in the prevention or treatment of diabetic complications.
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KEYWORD
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Lithospermum erythrorhizon, Boraginceae, Quantitative Analysis, Luteolin
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